Search results for "Memory Formation"
showing 5 items of 5 documents
The molecular links of re-emerging therapy: A review of evidence of Brahmi (Bacopa monniera)
2016
The convolution associated with memory is being resolved with advancement in neuroscience. According to the concurrent assumptions, synaptic plasticity forms one of the basis of memory formation, stabilization and strengthening. In Alzheimer's disease (AD), which is generally characterized by memory dysfunction, connections amongst the cells in the brain are attenuated or lost leading to degeneration of neural networks. Numerous attempts have been made to find new therapies for memory dysfunction with increasing attention and investments being laid on herbal drugs. Many herbal plants and extracts have already documented beneficial results when tested for antiamnesic effects. Brahmi (Bacopa …
The claustrum is a target for projections from the supramammillary nucleus in the rat.
2019
Injection of the anterograde tracer Phaseolus vulgaris leucoagglutinin (PHAL) into the rat rostral and caudal supramammillary nucleus (SUM) provided expected patterns of projections into the hippocampus and the septal region. In addition, unexpectedly intense projections were observed into the claustrum defined by parvalbumin expression. Injections of the retrograde tracer fluorogold (FG) into the hippocampus and the region of the claustrum showed that the cells of origin of these projections distributed similarly within the borders of the SUM. The SUM is usually involved in control of hippocampal theta activity, but the observation of intense projections into the claustrum indicates that i…
Modelling Spatial Memory
2018
Among the different capabilities of animals, the formation of spatial memories is crucial for their life. Living beings able to move, constantly need to orient themselves in the environment to reach a target that might be not always visible. This chapter investigates the process of spatial memory formation as an essential ingredient for orientation in open and unstructured environments. Neural centres devoted to spatial memory and path integration were deeply investigated both in rats and different insect species like ants, bees and fruit flies. In this chapter a neural-inspired model for the formation of a spatial working memory is discussed considering some key elements of the insect neur…
Role of the amygdala in antidepressant effects on hippocampal cell proliferation and survival and on depression-like behavior in the rat
2021
The stimulation of adult hippocampal neurogenesis by antidepressants has been associated with multiple molecular pathways, but the potential influence exerted by other brain areas has received much less attention. The basolateral complex of the amygdala (BLA), a region involved in anxiety and a site of action of antidepressants, has been implicated in both basal and stress-induced changes in neural plasticity in the dentate gyrus. We investigated here whether the BLA modulates the effects of the SSRI antidepressant fluoxetine on hippocampal cell proliferation and survival in relation to a behavioral index of depression-like behavior (forced swim test). We used a lesion approach targeting th…
A spiking network for spatial memory formation: Towards a fly-inspired ellipsoid body model
2013
Neural centers devoted to spatial memory and path integration were largely studied in rats and in different insect species like ants and bees. In this paper a neural-based model for the formation of a spatial working memory is proposed mirroring some peculiarities of the Drosophila central brain and in particular the ellipsoid body. Simulation results are reported opening the way to applications on roving platforms.